从“女性专属”到“男女共防”，默沙东加速全球HPV防控网构建

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鍙傝€冩枃鐚�細

1.涓�崕棰勯槻鍖诲�浼氱柅鑻椾笌鍏嶇柅鍒嗕細.瀛愬�棰堢檶绛変汉涔冲ご鐦ょ梾姣掔浉鍏崇柧鐥呭厤鐤��闃蹭笓瀹跺叡璇哰J]. 涓�崕棰勯槻鍖诲�鏉傚織, 2019, 53(8):761-803.

2. Ferlay J, Ervik M, Lam F, Laversanne M, Colombet M, Mery L, Pi帽eros M, Znaor A, Soerjomataram I, Bray F (China). Global Cancer Observatory: Cancer Today. Lyon, France: International Agency for Research on Cancer. Available from:

https://gco.iarc.who.int/today. [access on[2025-1-23]

3.鏈卞瓟閼�,绛�. HPV鐤�嫍鏈夋晥鎬х殑鐪熷疄涓栫晫鐮旂┒.涓�崕寰�敓鐗╁�鍜屽厤鐤��鏉傚織, 2023, 43(3) 230-238.

4.HPV and Cancer 鈥� NCI

5.WHO-Questions and Answers about HPV

6.Zou K, et al. Front Cell Infect Microbiol. 2022 Nov 24;12:1077651.

7.ONE-IN-THREE-MEN-WORLDWIDE-ARE-INFECTED-WITH-GENITAL-HUMAN-PAPILLOMAVIRUS. Access on[2023-9-1].

https://www.who.int/news/item/01-09-2023-one-in-three-men-worldwide-are-infected-with-genital-humanpapillomavirus

8.涔濅环浜轰钩澶寸槫鐥呮瘨鐤�嫍锛堥吙閰掗叺姣嶏級璇存槑涔�

9. Walboomers JM, Jacobs MV, Manos MM, Bosch FX, Kummer JA, Shah KV, Snijders PJ, Peto J, Meijer CJ, Mu帽oz N. Human papillomavirus is a necessary cause of invasive cervical cancer worldwide. J Pathol. 1999 Sep;189(1):12-9.

10. 涔斿弸鏋�. 涓�浗濡囧コ浜轰钩澶寸槫鐥呮瘨鎰熸煋鍜屽瓙瀹��鐧岀殑娴佽�鐥呭�鐮旂┒鐜扮姸鍙婂叾鐤�嫍棰勯槻鍓嶆櫙[J]. 涓�崕娴佽�鐥呭�鏉傚織,2007,28(10):937-940.

11. 鍏冪帿闆�, 绛�. 2016 骞翠腑鍥藉綊鍥犱簬浜轰钩澶寸槫鐥呮瘨鎰熸煋鐨勮偪鐦ゅ彂鐥呬笌姝讳骸鍒嗘瀽[J].涓�崕娴佽�鐥呭�鏉傚織. 2022, 43(5): 702-708.

a. 鐮旂┒璁捐�锛氳�鐮旂┒涓轰竴椤逛腑鍥紿PV 娴佽�鐥呭�鐮旂┒锛屾棬鍦ㄥ垎鏋�2016 骞存垜鍥藉綊鍥犱簬浜轰钩澶寸槫鐥呮瘨锛圚PV锛夋劅鏌撶殑鑲跨槫鍙戠梾鍜屾�浜℃儏鍐点€傜粨鍚堣偪鐦ゅ彂鐥呯巼銆佹�浜＄巼銆佸叏鍥戒汉鍙ｆ暟鍙婁汉缇ゅ綊鍥犲垎鍊硷紙PAF锛夎�绠�2016 骞村叏鍥戒笉鍚屽湴鍖恒€佷笉鍚屽勾榫勫強鐢锋€у拰濂虫€т汉缇ゅ綊鍥犱簬HPV 鎰熸煋鐨勮偪鐦ゅ彂鐥呮暟鍜屾�浜℃暟銆�

鐮旂┒缁撴灉锛�2016 骞村叏鍥芥湁124,772 渚嬶紙6.32/10 涓囷級鑲跨槫鏂板彂鐥呬緥褰掑洜浜嶩PV 鎰熸煋锛屽叾涓��棰堢檶鍜岃倹闂ㄧ檶鐨勫綊鍥犲垎鍊间负100%鍜�88%銆�

12. ANOGENITAL WARTS, SEXTUALLY TRANSMITTED INFECTIONS TREATMENT GUIDELINES, 2021. Access on[2021-7-22].

https://www.cdc.gov/std/treatment-guidelines/anogenital-warts.htm

13. 涓�崕鍖诲�浼氱毊鑲ゆ€х梾瀛﹀垎浼�,涓�浗鍖诲笀鍗忎細鐨�偆绉戝尰甯堝垎浼�,涓�浗搴峰�鍖诲�浼氱毊鑲ゆ€х梾濮斿憳浼�.涓�浗灏栭攼婀跨枺涓村簥璇婄枟鎸囧崡(2021 瀹屾暣鐗�)[J].涓�浗鐨�偆鎬х梾瀛︽潅蹇�,2021,35(04):359-374.

14. Liu M, et al. Sci Rep. 2015 ;5:10986.

b.鐮旂┒璁捐�锛氫竴椤� 2007-2009骞村湪涓�浗娌冲崡鐪佸畨闃冲競鍐滄潙寮€灞曠殑鍩轰簬浜虹兢鐨勯�绠＄檶闃熷垪鐮旂┒锛圓ECCS锛夈€傛牴鎹�暣缇ゆ娊鏍风殑鏂规硶锛岄€夊彇瀹夐槼甯傚啘鏉戠殑 9涓�潙浣滀负鐩�爣鏉戙€傛湰鐮旂┒閲囩敤浜嗕竴涓�瓙闃熷垪锛屽叾涓�寘鎷� 9涓�洰鏍囨潙搴勪腑鐨� 3涓�€備富瑕佺爺绌剁洰鐨勪负璇勪及澶��浜虹兢涓� HPV闃虫€т竴鑷寸巼銆佷紶鎾�巼鍙婄浉鍏抽�闄╁洜绱犮€傜爺绌跺�璞′负 25-65宀佷腑鍥藉啘鏉戝か濡伙紝鏍锋湰閲�874瀵癸紝鐮旂┒鏃堕暱 2009骞磣2013骞淬€傛�椤圭爺绌朵腑璇勪及鐨� HPV浼犳挱鍥犵礌鍖呮嫭鐮旂┒瀵硅薄鐨勫钩鍧囧勾榫勩€佸钩鍧囨€т即渚ｆ暟銆佹瘡鍛ㄦ€х敓娲婚�娆★紝浠ュ強鏁欒偛姘村钩銆佸伐浣滅被鍨嬨€丠PV鎸佺画鎰熸煋鎯呭喌銆�

鐮旂┒缁撴灉锛氬か濡囬棿 HPV浠讳竴鍨嬪埆銆佽嚧鐧屽瀷鍒�€侀潪鑷寸檶鍨嬪埆鎰熸煋鐨勪竴鑷存€у垎鍒�负 15.52%銆�16.18%銆�10.41%銆傚�浜庤嚧鐧屽瀷鍒�紝鐢锋€у悜濂虫€т紶鎾�殑椋庨櫓鏄捐憲楂樹簬濂虫€у悜鐢锋€т紶鎾�殑椋庨櫓銆傚�浜庨潪鑷寸檶鍨嬶紝鐢锋€у悜濂虫€т紶鎾�殑椋庨櫓鏄捐憲浣庝簬濂虫€у悜鐢锋€т紶鎾�€傚勾杞诲か濡囥€丠PV鎸佺画鎰熸煋銆佹€т即渚ｆ暟閲忚緝澶氥€佹€т氦棰戠巼杈冮珮涓庡か濡婚棿HPV鐩镐簰浼犳挱鍛堟�鐩稿叧銆�

15. 鏉庡弻,鏉庢槑鐝�,涓涢潚,绛�.浜轰钩澶寸槫鐥呮瘨鐤�嫍涓村簥搴旂敤涓�浗涓撳�鍏辫瘑[J].涓�浗濡囦骇绉戜复搴婃潅蹇�,2021,22(02):225-234.

16. 鐜嬩复铏�,璧垫洿鍔�.瀛愬�棰堢檶缁煎悎闃叉帶鎸囧崡(绗�2 鐗�)[M].鍖椾含:浜烘皯鍗�敓鍑虹増绀�.2023.6

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